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Impact of therapy with alpha-lipoic acid (ALA) on the oxidative stress in the controlled NIDDM: a possible preventive way against the organ dysfunction?   Gianturco V1, Bellomo A, D'Ottavio E, Formosa V, Iori A, Mancinella M, Troisi G, Marigliano V.  Arch Gerontol Geriatr. 2009;49 Suppl 1:129-33. doi: 10.1016/j.archger.2009.09.022.

Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.
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Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS.
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Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy.       Nagamatsu M1, Nickander KK, Schmelzer JD, Raya A, Wittrock DA, Tritschler H, Low PA.  Diabetes Care. 1995 Aug;18(8):1160-7.

Potential Protective Role of Rutin and Alpha-lipoic Acid Against Cisplatin-induced Nephrotoxicity in Rats.
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Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial.         Gary W. Small M.D., Prabha Siddarth Ph.D., Zhaoping Li M.D., Ph.D., Karen J. Miller Ph.D., Linda Ercoli Ph.D., Natacha D. Emerson M.A., Jacqueline Martinez M.B.A., M.S., Koon-Pong Wong Ph.D., Jie Liu Ph.D., David A. Merrill M.D., Ph.D., Stephen T. Chen M.D., Susanne M. Henning Ph.D., R.D., Nagichettiar Satyamurthy Ph.D., Sung-Cheng Huang D.Sc., David Heber M.D., Ph.D., Jorge R. Barrio Ph.D.  The American Journal of Geriatric Psychiatry,  Volume 26, Issue 3, March 2018, Pages 266-277.!

Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence.  Ritesh Kotecha, Akiyoshi Takami, and J. Luis Espinoza.  Oncotarget. 2016 Aug 9; 7(32): 52517–52529.

Chronic Inflammation, National Cancer Institute

Prevention and treatment of cancer targeting chronic inflammation: research progress, potential agents, clinical studies and mechanisms.    Zhang Y, Kong W, Jiang J.      Sci China Life Sci. 2017 Jun;60(6):601-616.

Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression Jae-Hoon Jeong, Jee Young An, Yong Tae Kwon, Juong G. Rhee, and Yong J. Lee.   J Cell Biochem. 2009 Jan 1; 106(1): 73–82.

Quercetin, Inflammation and Immunity.  Yao Li, Jiaying Yao, Chunyan Han, Jiaxin Yang, Maria Tabassum Chaudhry, Shengnan Wang, Hongnan Liu, and Yulong Yin.  Nutrients. 2016 Mar; 8(3): 167.

Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages.   Lo AH1, Liang YC, Lin-Shiau SY, Ho CT, Lin JK. Carcinogenesis. 2002 Jun;23(6):983-91.

Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Surh YJ.    Food Chem Toxicol. 2002 Aug;40(8):1091-7.

Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat.   Guardia T, Rotelli AE, Juarez AO, Pelzer LE. Farmaco. 2001 Sep;56(9):683-7.

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α-Pinene (Boswellia)  Induces Apoptotic Cell Death via Caspase Activation in Human Ovarian Cancer Cells.  Hou J, Zhang Y2, Zhu Y, Zhou B, Ren C, Liang S, Guo Y. Med Sci Monit. 2019 Sep 4;25:6631-6638.

Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation.  Chun KS, Keum YS, Han SS, Song YS, Kim SH, Surh YJ.     Carcinogenesis. 2003 Sep;24(9):1515-24.

Recent advances in natural therapeutic approaches for the treatment of cancer.  Wang XJ, Chen JY, Fu LQ, Yan MJ.    J Chemother. 2020 Jan 13:1-13.

Epigenetics/epigenomics and prevention by curcumin of early stages of inflammatory-driven colon cancer.  Wu R, Wang L1,2, Yin R, Hudlikar R, Li S, Kuo HD, Peter R, Sargsyan D, Guo Y, Liu X, Kong AT.     Mol Carcinog. 2020 Feb;59(2):227-236.

Curcumin - A Novel Therapeutic Agent In The Prevention Of Colorectal Cancer.  Gupta MK, Vadde R, Sarojamma V. Curr Drug Metab. 2019 Oct 7.

Curcumin induces cell apoptosis in human chondrosarcoma through extrinsic death receptor pathway  Hsiang-Ping LeeTe-Mao LiJung-Ying TsaoYi-Chin FongChih-Hsin Tang.  International Immunopharmacology. Volume 13, Issue 2, June 2012, Pages 163-169.

Chemopreventive and therapeutic potential of curcumin in esophageal cancer: Current and future status.  Hesari A, Azizian M, Sheikhi A, Nesaei A, Sanaei S, Mahinparvar N, Derakhshani M, Hedayt P, Ghasemi F, Mirzaei H.     Int J Cancer. 2019 Mar 15;144(6):1215-1226.

The versatile role of curcumin in cancer prevention and treatment: A focus on PI3K/AKT pathway.  Hamzehzadeh L, Atkin SL, Majeed M, Butler AE, Sahebkar A.     J Cell Physiol. 2018 Oct;233(10):6530-6537.

Curcumin ameliorates palmitate-induced inflammation in skeletal muscle cells by regulating JNK/NF-kB pathway and ROS production.     Sadeghi A, Rostamirad A, Seyyedebrahimi S, Meshkani R.     Inflammopharmacology. 2018 Oct;26(5):1265-1272.

DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice.     Guo Y, Wu R, Gaspar JM, Sargsyan D, Su ZY, Zhang C, Gao L, Cheng D, Li W, Wang C, Yin R, Fang M, Verzi MP, Hart RP, Kong AN.     Carcinogenesis. 2018 May 3;39(5):669-680.

Inhibition of hepatocellular carcinoma tumorigenesis by curcumin may be associated with CDKN1A and CTGF. Zeng Y, Shen Z, Gu W, Wu M.   Gene. 2018 Apr 20;651:183-193.

Chemopreventive and Antitumor Efficacy of Curcumin in a Spontaneously Developing Hen Ovarian Cancer Model.     Sahin K, Orhan C, Tuzcu M, Sahin N, Tastan H, Özercan İH, Güler O, Kahraman N, Kucuk O, Ozpolat B.      Cancer Prev Res (Phila). 2018 Jan;11(1):59-67.

Anti-tumor bioactivities of curcumin on mice loaded with gastric carcinoma.   Wang XP, Wang QX, Lin HP, Chang N.    Food Funct. 2017 Sep 20;8(9):3319-3326.

Curcumin: the spicy modulator of breast carcinogenesis.   Banik U, Parasuraman S, Adhikary AK, Othman NH.     J Exp Clin Cancer Res. 2017 Jul 19;36(1):98.

The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells.   Hallman K, Aleck K, Dwyer B, Lloyd V, Quigley M, Sitto N, Siebert AE, Dinda S.      Breast Cancer (Dove Med Press). 2017 Mar 10;9:153-161.

Curcumin: a Polyphenol with Molecular Targets for Cancer Control.   Qadir MI, Naqvi ST, Muhammad SA.     Asian Pac J Cancer Prev. 2016;17(6):2735-9.

Curcumin-albumin conjugates as an effective anti-cancer agent with immunomodulatory properties.  Aravind SR, Krishnan LK.     Int Immunopharmacol. 2016 May;34:78-85.

Prevention from radiation damage by natural products.   Fischer N, Seo EJ, Efferth T.    Phytomedicine. 2018 Aug 1;47:192-200.

A novel lecithin-based delivery form of Boswellic acids as complementary treatment of radiochemotherapy-induced cerebral edema in patients with glioblastoma multiforme: a longitudinal pilot experience.   Di Pierro F, Simonetti G, Petruzzi A, Bertuccioli A, Botta L, Bruzzone MG, Cuccarini V, Fariselli L, Lamperti E.     J Neurosurg Sci. 2019 Jun;63(3):286-291.

Boswellic acid has anti-inflammatory effects and enhances the anticancer activities of Temozolomide and Afatinib, an irreversible ErbB family blocker, in human glioblastoma cells.   Barbarisi M, Barbarisi A, De Sena G, Armenia E, Aurilio C, Libutti M, Iaffaioli RV, Botti G, Maurea N, Quagliariello V.     Phytother Res. 2019 Jun;33(6):1670-1682.

Boswellia frereana suppresses HGF-mediated breast cancer cell invasion and migration through inhibition of c-Met signalling.  Parr C, Ali AY.      J Transl Med. 2018 Oct 12;16(1):281.

Combined acetyl-11-keto-β-boswellic acid and radiation treatment inhibited glioblastoma tumor cells. Conti S, Vexler A, Edry-Botzer L, Kalich-Philosoph L, Corn BW, Shtraus N, Meir Y, Hagoel L, Shtabsky A, Marmor S, Earon G, Lev-Ari S.     PLoS One. 2018 Jul 3;13(7).

Boswellic Acid Improves Cognitive Function in a Rat Model Through Its Antioxidant Activity: - Neuroprotective effect of Boswellic acid.   Ebrahimpour S, Fazeli M, Mehri S, Taherianfard M, Hosseinzadeh H.    J Pharmacopuncture. 2017 Mar;20(1):10-17.

Pharmacological evidences for cytotoxic and antitumor properties of Boswellic acids from Boswellia serrata. Khan MA, Ali R2, Parveen R, Najmi AK, Ahmad S.     J Ethnopharmacol. 2016 Sep 15;191:315-323.

Prediction of anticancer property of bowsellic acid derivatives by quantitative structure activity relationship analysis and molecular docking study.   Satpathy R, Guru RK, Behera R, Nayak B.     J Pharm Bioallied Sci. 2015 Jan-Mar;7(1):21-5.

Acetyl-11-keto-β-boswellic acid (AKBA) inhibits human gastric carcinoma growth through modulation of the Wnt/β-catenin signaling pathway.   Zhang YS, Xie JZ, Zhong JL, Li YY, Wang RQ, Qin YZ, Lou HX, Gao ZH, Qu XJ.   Biochim Biophys Acta. 2013 Jun;1830(6):3604-15.

Enhanced anticancer potential of encapsulated solid lipid nanoparticles of TPD: a novel triterpenediol from Boswellia serrata.    Bhushan S, Kakkar V, Pal HC, Guru SK, Kumar A, Mondhe DM, Sharma PR, Taneja SC, Kaur IP, Singh J, Saxena AK.    Mol Pharm. 2013 Jan 7;10(1):225-35.

Acetyl-11-keto-β-boswellic acid (AKBA) Attenuates Oxidative Stress, Inflammation, Complement Activation and Cell Death in Brain Endothelial Cells Following OGD/Reperfusion.   Ahmad S, Khan SA, Kindelin A, Mohseni T, Bhatia K, Hoda MN, Ducruet AF.     Neuromolecular Med. 2019 Dec;21(4):505-516.

Anti-inflammatory and anti-arthritic effects of methanol extract of the stem bark of Boswellia dalzielii Hutch (Burseraceae) in rats.   Mbiantcha M, Almas J, Atsamo AD, Ateufack G, Shabana SU, Bomba Tatsinkou DF, Yousseu Nana W, Nida D.    Inflammopharmacology. 2018 Dec;26(6):1383-1398.

Boswellia serrata has beneficial anti-inflammatory and antioxidant properties in a model of experimental colitis.   Hartmann RM1, Fillmann HS, Martins MI, Meurer L, Marroni NP.     Phytother Res. 2014 Sep;28(9):1392-8.

Plant food supplements with anti-inflammatory properties: a systematic review (II).  Di Lorenzo C, Dell'Agli M, Badea M, Dima L, Colombo E, Sangiovanni E, Restani P, Bosisio E. Crit Rev Food Sci Nutr. 2013;53(5):507-16.

Boswellia serrata, a potential antiinflammatory agent: an overview.   Siddiqui MZ. Indian J Pharm Sci. 2011 May;73(3):255-61.

Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers.   Yadav VR, Prasad S, Sung B, Gelovani JG, Guha S, Krishnan S, Aggarwal BB.    Int J Cancer. 2012 May 1;130(9):2176-84.

Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer.   Delmas D, Lançon A, Colin D, Jannin B, Latruffe N.   Curr Drug Targets. 2006 Apr;7(4):423-42.

Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.   Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y.    Anticancer Res. 2004 Sep-Oct;24(5A):2783-840.

Resveratrol, a natural chemopreventive agent against degenerative diseases.   Ignatowicz E, Baer-Dubowska W.    Pol J Pharmacol. 2001 Nov-Dec;53(6):557-69.

Resveratrol as an anticancer nutrient: molecular basis, open questions and promises.   Signorelli P, Ghidoni R.     J Nutr Biochem. 2005 Aug;16(8):449-66.

Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells.   Clément MV, Hirpara JL, Chawdhury SH, Pervaiz S.    Blood. 1998 Aug 1;92(3):996-1002.

Resveratrol modulation of signal transduction in apoptosis and cell survival: a mini-review.   Fulda S, Debatin KM.    Cancer Detect Prev. 2006;30(3):217-23.

Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-kappaB and AP-1 as prime targets.   Kundu JK, Shin YK, Surh YJ.    Biochem Pharmacol. 2006 Nov 30;72(11):1506-15.

Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity.  Kundu JK, Shin YK, Kim SH, Surh YJ.     Carcinogenesis. 2006 Jul;27(7):1465-74.

Rutin and curcumin reduce inflammation, triglyceride levels and ADA activity in serum and immune cells in a model of hyperlipidemia.     Manzoni AG, Passos DF, da Silva JLG, Bernardes VM, Bremm JM, Jantsch MH, de Oliveira JS, Mann TR, de Andrade CM, Leal DBR.      Blood Cells Mol Dis. 2019 May;76:13-21.

Rutin inhibits carfilzomib-induced oxidative stress and inflammation via the NOS-mediated NF-κB signaling pathway.  Al-Harbi NO, Imam F, Al-Harbi MM, Al-Shabanah OA, Alotaibi MR, As Sobeai HM, Afzal M, Kazmi I, Al Rikabi AC.    Inflammopharmacology. 2019 Aug;27(4):817-827.

Rutin attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation and apoptosis in fluoride treated rats.    Nkpaa KW, Onyeso GI.     Neurosci Lett. 2018 Aug 24;682:92-99.

Enhancement of anti-inflammatory activity of polyphenolic flavonoid rutin by encapsulation.   Jantrawut P, Phongpradist R, Muller M, Viernstein H.    Pak J Pharm Sci. 2017 Sep;30(5):1521-1527.

Treatment with Rutin - A Therapeutic Strategy for Neutrophil-Mediated Inflammatory and Autoimmune Diseases: - Anti-inflammatory Effects of Rutin on Neutrophils.  Nikfarjam BA, Adineh M, Hajiali F, Nassiri-Asl M.  J Pharmacopuncture. 2017 Mar;20(1):52-56.

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols.  Jessy Moore, Michael Yousef, and Evangelia Tsiani. Nutrients. 2016 Nov; 8(11): 731.

Effect of Some Clinically Used Proteolytic Enzymes on Inflammation in Rats.  A. H. M. Viswanatha Swamy* and P A. Patil. Indian J Pharm Sci. 2008 Jan-Feb; 70(1): 114–117.


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Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function.  Sinha R, Sinha I, Calcagnotto A, Trushin N, Haley JS, Schell TD, Richie JP Jr.     Eur J Clin Nutr. 2018 Jan;72(1):105-111.

Effect of whey protein isolate on intracellular glutathione and oxidant-induced cell death in human prostate epithelial cells.   Kent KD1, Harper WJ, Bomser JA.     Toxicol In Vitro. 2003 Feb;17(1):27-33.

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Glutathione Peroxidase 1 Activity and Cardiovascular Events in Patients with Coronary Artery Disease  Stefan Blankenberg, M.D., Hans J. Rupprecht, M.D., Christoph Bickel, M.D., Michael Torzewski, M.D., Gerd Hafner, M.D., Laurence Tiret, Ph.D., Marek Smieja, M.D., Ph.D., François Cambien, M.D., Jürgen Meyer, M.D., and Karl J. Lackner, M.D. for the AtheroGene Investigators.  N Engl J Med October 23, 2003; 349:1605-1613

Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study.  Honda Y, Kessoku T, Sumida Y, Kobayashi T, Kato T, Ogawa Y, Tomeno W, Imajo K, Fujita K, Yoneda M, Kataoka K, Taguri M, Yamanaka T, Seko Y, Tanaka S, Saito S, Ono M, Oeda S, Eguchi Y, Aoi W, Sato K, Itoh Y, Nakajima A.   BMC Gastroenterol. 2017 Aug 8;17(1):96.

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Glutathione in the prevention of cisplatin induced toxicities. A prospectively randomized pilot trial in patients with head and neck cancer and non small cell lung cancer.  Schmidinger M1, Budinsky AC, Wenzel C, Piribauer M, Brix R, Kautzky M, Oder W, Locker GJ, Zielinski CC, Steger GG.     Wien Klin Wochenschr. 2000 Jul 28;112(14):617-23.

Prevention of oxaliplatin-related neurotoxicity by glutathione infusions. Takimoto N, Sugawara S, Iida A, Sakakibara T, Mori K, Sugiura M, Yamamoto M, Tanaka M, Hayakawa T, Yamamura K, Adachi M.    Gan To Kagaku Ryoho. 2008 Dec;35(13):2373-6.

Neuroprotective effect of reduced glutathione on oxaliplatin-based chemotherapy in advanced colorectal cancer: a randomized, double-blind, placebo-controlled trial.  Cascinu S, Catalano V, Cordella L, Labianca R, Giordani P, Baldelli AM, Beretta GD, Ubiali E, Catalano G.      J Clin Oncol. 2002 Aug 15;20(16):3478-83.

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Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials.  Autier P, Gandini S.    Arch Intern Med. 2007 Sep 10;167(16):1730-7.

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Vitamin D Supplementation and Survival of Patients with Non-small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial.  Akiba T, Morikawa T, Odaka M, Nakada T, Kamiya N, Yamashita M, Yabe M, Inagaki T, Asano H, Mori S, Tsukamoto Y, Urashima M.     Clin Cancer Res. 2018 Sep 1;24(17):4089-4097.

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Effect of Vitamin D on Relapse-Free Survival in a Subgroup of Patients with p53 Protein-Positive Digestive Tract Cancer: A Post Hoc Analysis of the AMATERASU Trial.  Akutsu T, Okada S, Hirooka S, Ikegami M, Ohdaira H, Suzuki Y, Urashima M.    Cancer Epidemiol Biomarkers Prev. 2019 Dec 23.

Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-κB pathway activation through RPS3.  Huang Z, Zhang Y, Li H, Zhou Y, Zhang Q, Chen R, Jin T, Hu K, Li S, Wang Y, Chen W, Huang Z.    Cell Death Dis. 2019 Dec 9;10(12):936.

25-Hydroxyvitamin D at time of breast cancer diagnosis and breast cancer survival.  Kanstrup C, Teilum D, Rejnmark L, Bigaard JV, Eiken P, Kroman N, Tjønneland A, Mejdahl MK.    Breast Cancer Res Treat. 2019 Nov 9.

Meta-analysis of randomized controlled trials on vitamin D supplement and cancer incidence and mortality.  Zhang X, Niu W. Biosci Rep. 2019 Nov 29;39(11). pii: BSR20190369.

Negative Impact of 25-hydroxyvitamin D Deficiency on Breast Cancer Survival.  Thanasitthichai S, Prasitthipayong A, Boonmark K, Purisa W, Guayraksa K. Asian Pac J Cancer Prev. 2019 Oct 1;20(10):3101-3106.

25-Hydroxyvitamin D and Total Cancer Incidence and Mortality: A Meta-Analysis of Prospective Cohort Studies.  Han J, Guo X, Yu X, Liu S, Cui X, Zhang B, Liang H.     Nutrients. 2019 Sep 26;11(10).

The effects of serum levels, and alterations in the genes of binding protein and receptor of vitamin D on gastric cancer.  Durak Ş, Gheybi A, Demirkol Ş, Arıkan S, Zeybek ŞÜ, Akyüz F, Yaylım İ, Küçükhüseyin Ö.    Mol Biol Rep. 2019 Dec;46(6):6413-6420.

Plasma 25-Hydroxyvitamin D Levels and Survival in Patients with Advanced or Metastatic Colorectal Cancer: Findings from CALGB/SWOG 80405 (Alliance).  Yuan C, Sato K, Hollis BW, Zhang S, Niedzwiecki D, Ou FS, Chang IW, O'Neil BH, Innocenti F, Lenz HJ, Blanke CD, Goldberg RM, Venook AP, Mayer RJ, Fuchs CS, Meyerhardt JA, Ng K. Clin Cancer Res. 2019 Dec 15;25(24):7497-7505.

Serum 25-hydroxyvitamin D levels predict cancer survival: a prospective cohort with measurements prior to and at the time of cancer diagnosis.   Robsahm TE, Tretli S, Torjesen PA, Babigumira R, Schwartz GG.    Clin Epidemiol. 2019 Aug 8;11:695-705.

24R,25-dihydroxyvitamin D3 modulates tumorigenicity in breast cancer in an estrogen receptor-dependent manner.  Verma A, Schwartz Z, Boyan BD.    Steroids. 2019 Oct;150:108447.

The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review   Adriana J. van Ballegooijen, Stefan Pilz, Andreas Tomaschitz, Martin R. Grübler, and Nicolas Verheyen.     Int J Endocrinol. 2017; 2017: 7454376.

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The effect of Pyrroloquinoline quinone and Resveratrol on the Survival and Regeneration of Cerebellar Granular Neurons. Shanan N, GhasemiGharagoz A, Abdel-Kader R, Breitinger HG. Neurosci Lett. 2019 Feb 16;694:192-197. 

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