Risk of Breast Cancer? Do you know your Estrogen Metabolites?
Estrogen alone is not the issue when it comes to increasing the risk of breast cancer. The real issue is how is your estrogen being metabolized. You want to have your doctor order a test that evaluates the estrogen metabolites. **I recommend the Dutch Test (https://dutchtest.com) or the Rhein Hormone Test (http://www.rheinlabs.com)
The liver converts estrogens into estrogen metabolites. Three of estrogen’s metabolites, the breakdown products of this hormone, are 2-hydroxyestrone, 4-hydroxyestrone, and 16-alpha-hydroxyestrone.
Since the 1980s, 2-hydroxyestrone has been considered a “good” or chemoprotective form of estrogen, while 16-alpha-hydroxyestrone has been associated with the development of cancer. It can fuel the growth and division of hormone-dependent and other cancer cells more than the 2-hydroxyestrones can. The 2-hydroxyestrones, in contrast, have almost no estrogenic effect. Prevailing evidence has shown that the ratio of 2-hydroxyestrone to 16-alpha-hydroxyestrone is relevant as a risk factor for estrogen-sensitive cancers, including breast and cervical cancers. Simply put, when it comes to estrogen metabolites, you want more 2s than 16s. And guess what can help the body do that? Cruciferous vegetables.
My two personal favorite supplements that I use and recommend for my patients can be seen here: https://advancednutrition.ehealthpro.com/t/advancednutrition/estrogen-support
Article written by Ronald Grisanti D.C., D.A.B.C.O., D.A.C.B.N., M.S.,CFMP from www.FunctionalMedicineUniversity.com
with Added content by Dr. Dylan Foster, D.C., P.S.c.D., C.F.M.P., O.N.C. from PostChemoNutrition.com
Winters Nasha, Kelley Jess, The Metabolic Approach to Cancer, Chelsea Green Publishing, 2017
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Heather Greenlee, Yu Chen, Geoffrey C. Kabat, Qiao Wang, Muhammad G. Kibriya, Irina Gurvich, Daniel W Sepkovic, et al., “Variants in Estrogen Metabolism and Biosynthesis Genes and Urinary Estrogen Metabolites in Women with a Family History of Breast Cancer,” Breast Cancer Research and Treatment 102, no. 1 (March 2007): 111-17