Breast Cancer and Curcumin

Watch with Dr. Foster of Post Chemo Nutrition as he goes over a study from the Journal of Experimental and Clinical Cancer Research titled “Curcumin: The Spicy Modulator of Breast Carcinogenesis”. Can be found at: https://pubmed.ncbi.nlm.nih.gov/28724427/ Discover the amazing benefits of curcumin on breast cancer prevention from this research article.

 

TRANSCRIPT:

Curcumin and breast cancer. Today’s topic is just that, curcumin and breast cancer, and how it can affect or help you. We are going to review a article from the Journal of Experimental and Clinical Cancer Research right here in PubMed, and it is titled “Curcumin: the spicy modulator of breast carcinogenesis” which is the spreading and making of new cancer cells, typically from healthy cells. This is a very important topic for those of you that are dealing with breast cancer and you’re looking for prevention or treatment options.

What I want to talk about and why I’m talking about it is because if you go to my website, postchemonutrition, and go to products and Cell Revive, you will see that in Cell Revive we have, one of our ingredients… We have a couple of ingredients, obviously, but we have curcumin in quite a few of our products. Here we have it in Mito Cell and Inflam Redux.

It’s a very big component of our ingredients because it’s got some benefits from what I’ve found in my research. Now, with that being said, we are going into education, research, so follow on with me here. Education, research, because today’s topic about curcumin, the spicy modulator, is under research so you can find this article right here under Cell Revive… loading up, and then obviously Cell Revive is in… one of the ingredients is Inflam Redux that has curcumin in it.

Right down, right here, so this is what we’re talking about today. It’s not that one, this one. Curcumin, that novel therapeutic agent and the prevention of colo… Whoops, wrong one, sorry. Colorectal cancer. Where is it at? Well, that’s a good one though, but we’re talking about breast cancer today. Where did it go? Curcumin, it’s also a novel approach. Well, I know it’s in here. Gosh, darn it. Where are you at?

Curcumin. Here we go. Sorry about that guys, I was off. I got so many research articles in here. Speaking of which, if you’re looking for some research articles, this is all on the ingredients in our Cell Revive byproduct, by the way. This is what we’re talking about today. Curcumin: the spicy modulator of breast carcinogenesis.

You can see, I have a ton of different studies, research articles, and that’s why I made my product of Cell Revive, a post chemo nutrition, because I wanted the best I wanted what has been researched. Today’s topic, obviously, there’s this here we’re talking about, but I got the PDF here I downloaded so I can highlight it. I’m just going to talk about some basics on it. Obviously, I’m not going to talk about the whole thing because it’s too long, so we’re just going to review the overview and some highlights that I’ve found in here that I like to represent.

This review primarily underscores the modulatory effects of curcumin on the cancer hallmarks. The focus is its anticancer effects and the complex pathways of breast carcinogenesis. Curcumin modulates breast carcinogenesis through its effects on cell cycle and proliferation (which is spreading and reproduction), apoptosis (the destruction, the killing of cancerous cells), senescence, cancer spread and angiogenesis (so the making of new blood vessels).

Breast cancer is the second most common cancer in the world, that’s very common, unfortunately, it’s also the most common cancer among women, and it’s the fifth cause of death of all cancers, fifth leading cause of death for cancer. It still remains, breast cancer still remains a lethal disease. Even though we’ve come a long ways, it’s still a very lethal disease.

Now, the green is my highlight here. Natural products are now becoming significant option in breast cancer prevention and treatment. A lot of people always say natural products don’t work, nothing natural works, but as you can see, I got a lot of studies about natural stuff. This study here from the Journal of Experimental and Clinical Cancer Research, is stating that natural products have become significant option in breast cancer prevention and treatment.

Well-known use of these in cancer treatments are due to their effectiveness and less side effects, relatively low costs, because cancer treatments are not cheap, and notably their ability to target various signaling pathways. One of the most noteworthy of these natural compounds is curcumin. That’s why we’re talking about curcumin in this research article today.

Curcumin, if you don’t know what it is, it’s basically a constituent of a plant, a spice called turmeric, that’s where it comes from. It’s bright yellow. It interacts with different arsenals of molecules including inflammatory mediators, so it helps with inflammatory mediators, growth factors, enzymes, carrier proteins, metal ions, tumor suppressors, transcription factors, oncoproteins and cellular nucleic acids. Basically, it affects a lot of different factors and pathways in good ways.

The therapeutic properties of curcumin include antioxidant, which is important, antiarthritic which is good for joints, antiamyloid, so for plaquing and stuff, anti-ischemic and anti-inflammatory effects. It has been shown to have protective and therapeutic efficiency against cancers of the skin, oral cavity, lungs, pancreas, and intestinal tract. That’s a lot of benefits right there.

It also has been found to suppress tumor angiogenesis and metastasis. Sorry, mouth is dry. It suppresses tumor angiogenesis and metastasis, so basically the spreading and growth of new cancerous cells. Curcumin on breast cancer impedes the growth of various cancer cells without producing any cytotoxicity to normal cells.

As you know, if you’ve done chemo or radiation therapy, they all damage both cancer cells and healthy cells. Whereas curcumin, it’s just targeting or helping just target cancer cells, but they don’t produce, it doesn’t produce any toxicity to your normal healthy cells. Again, less side effects, right? Pretty awesome.

According to this article, curcumin has strong effects on both intrinsic and extrinsic pathways of apoptosis. Basically, it helps kill off bad cells. Naturally, it’s self-destruction of cancerous cells in different pathways.

We’re going down here, I’m trying to keep the short for you all. The IGF system, basically insulin like growth factor system helps spread cancerous cells right here. It talks about it’s a critical role in breast cancer. Curcumin helps suppress this gene expression. That’s good, right? It helps suppress that, it helps suppress the spread of the IGF-1 pathways.

Curcumin has effectively demonstrated its efficiency to act as a potent antiangiogenic, and anti-invasive and anti-metastatic agent. Again, it helps with a lot of different components of helping protect against these ways of different cancer mechanisms. Curcumin repressed tumor growth, so it helps stop tumor growth or slowed it down, and microvessels, so basically angiogenesis in mouse models, and inhibited migratory activity of cancer cells. So from spreading it helps inhibit the spread of new cancer cells. Cool. Taking over different spots. It got a lot of benefits.

Cancer… it can suppress tumor growth. Curcumin has shown to upregulate this maspin expression in breast cancer cells. That’s what maspin been, basically it’s something that can help suppress tumor growth and the spread of cancer cells different tumor situations in vitro and in vivo, but curcumin helps upregulate it, so it helps it work better, it helps express itself better. That’s another good benefit of curcumin.

We’re getting down there. We’re almost done. Chronic inflammation aids the growth and spread of cancer cells. Again, our Cell Revive product is designed to focus on helping with inflammation properties, mitochondrial function, cell repair, things like that. That’s why we have a lot of curcumin in there which has been found to aid in many aspects of cancer suppression according to this article.

Curcumin can inhibit, this is iNOS which is inducible nitric oxide synthase induction, scavenged nitric oxide radicals in breast organ cultures, and reduce free radical synthesis because free radicals help spread the cancer cells. It reduces the carcinogenesis again. Alone or in combination with piperine which is a brand name, basically it’s black pepper, it is able to inhibit breast stem cell, inhibit breast stem cells.

This is good because a lot of times when we’re dealing with cancer, a lot of stem cells will stay even though you’ve done a lot of chemo, radiation and surgery, the stem cells stay and they can start reproducing again. That’s why a lot of times when they don’t have any positive findings of cancer and they still say, “Well, let’s do another round just to be safe of chemo or radiation because I want to make sure they get all those stem cells.” Well, it has been found to inhibit those cancerous breast stem cells.

It can serve as an effective cancer preventing approach. Look at that. In breast cancer, curcumin can reverse this repression of natural killer cell cytotoxicity. It helps with natural killer cells which is really good because they can contribute as well. Curcumin exemplifies a promising natural anticancer agent for breast cancer prevention and treatment. This is probably the biggest, most important takeaway right here.

Curcumin exemplifies a promising natural anticancer agent for breast cancer prevention and treatment. Curcumin and its analogues have been found to inhibit cancer cell proliferation, promote apoptosis, so basically the spread of new cancerous cells, the killing of or self-destructing of their own cancerous cells, and has a lot of different components in healing.

In conclusion, breast cancer curcumin impedes tumor growth, malignant progression, and the spread. Breast cancer curcumin impedes tumor growth, malignant progression and the spread. Good all curcumin. Again, that’s why it’s in Cell Revive. What I found is that, oops, sorry, we’ll go over here in our Cell Revive product on postchemonutrition.com.

We have a lot of ingredients in there in Cell Revive, and these are the studies of all the ingredients. There’s just a ton of them. There’s many more I could put on there but there’s only I can do so much. Ultimately, the ingredients are on here. You can see there’s actually two pages of ingredients, this is one of them.

Like in my Mito Cell and Inflam Redux that we do have curcumin, here’s our turmeric and curcumin. Then over here we also have our curcuminoids. The reason for them being mixed with all these other ingredients is because I found it works better than by itself.

So, thank you for watching. I hope this helps gain some insight and information. This is just educational purposes only. Please do not try to treat cancer by yourself, you need to go see your oncologist. This is just educational information. I am more on the side of focusing on prevention and reduction of recurrences, which is why I made Cell Revive product and Post Chemo Nutrition. It’s not designed to be used during cancer therapies and treatments.

Please talk to your oncologist, if you have any questions, feel free to email me. Other than that, please have a wonderful day. I’m Dr. Dylan Foster and I’m out of here.