ZEOLITES

Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo  Sandra Kraljević Pavelić, Jasmina Simović Medica, Darko Gumbarević, Ana Filošević, Nataša Pržulj, and Krešimir Pavelić, Front Pharmacol. 2018; 9: 1350.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277462/

ZEOLITE: "THE MAGIC STONE"; MAIN NUTRITIONAL, ENVIRONMENTAL, EXPERIMENTAL AND CLINICAL FIELDS OF APPLICATION.  Laurino C1, Palmieri B1. Nutr Hosp. 2015 Aug 1;32(2):573-81. doi: 10.3305/nh.2015.32.2.8914. https://www.ncbi.nlm.nih.gov/pubmed/26268084

[What a physician should know about zeolites]. [Article in Croatian]  Boranić M. Lijec Vjesn. 2000 Nov-Dec;122(11-12):292-8. https://www.ncbi.nlm.nih.gov/pubmed/11291273

Removal of heavy metals from mine waters by natural zeolites. Wingenfelder U, Hansen C, Furrer G, Schulin R.  Environ Sci Technol. 2005 Jun 15;39(12):4606-13.   https://www.ncbi.nlm.nih.gov/pubmed/16047799

Zeolites as Carriers of Antitumor Ribonuclease Binase.  Vera Khojaewa, Oleg Lopatin, Pavel Zelenikhin, and Olga Ilinskaya Front Pharmacol. 2019; 10: 442.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509225/

Treatment of radioactive liquid waste by sorption on natural zeolite in Turkey.  Osmanlioglu AE.  J Hazard Mater. 2006 Sep 1;137(1):332-5.  https://www.ncbi.nlm.nih.gov/pubmed/16563616

Modulation of the Bifidobacterial Communities of the Dog Microbiota by Zeolite.  Alberto Sabbioni, Chiara Ferrario, Christian Milani, Leonardo Mancabelli, Enzo Riccardi, Francesco Di Ianni, Valentino Beretti, Paola Superchi, and Maria C. Ossiprandi.  Front Microbiol. 2016; 7: 1491..  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031887/

Zeolite food supplementation reduces abundance of enterobacteria.  Prasai TP, Walsh KB, Bhattarai SP, Midmore DJ, Van TT, Moore RJ, Stanley D.  Microbiol Res. 2017 Jan;195:24-30.  https://www.ncbi.nlm.nih.gov/pubmed/28024523/

Activated and Micronized Zeolite in the Modulation of Cellular Oxidative Stress in Mexican Smokers: A Randomized Clinical Trial.  Atitlán-Gil A, Bretón-de la Loza MM, Jiménez-Ortega JC, Belefant-Miller H, Betanzos-Cabrera G.  Rev Invest Clin. 2017 May-Jun;69(3):146-151.  https://www.ncbi.nlm.nih.gov/pubmed/28613284

Clinical evidence supporting the use of an activated clinoptilolite suspension as an agent to increase urinary excretion of toxic heavy metals.   Flowers J, Lonky SA, Deitsch EJ.  https://www.dovepress.com/clinical-evidence-supporting-the-use-of-an-activated-clinoptilolite-su-peer-reviewed-article-NDS   Published 4 November 2009 Volume 2009:1 Pages 11—18

 Neuroprotective Actions of Clinoptilolite and Ethylenediaminetetraacetic Acid Against Lead-induced Toxicity in Mice Mus musculus.  Mahaboob P. Basha, Shabana Begum,1 and Bilal Ahmed Mir.  Toxicol Int. 2013 Sep-Dec; 20(3): 201–207. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877486/

Modified natural clinoptilolite detoxifies small mammal's organism loaded with lead I. Lead disposition and kinetic model for lead bioaccumulation.    Beltcheva M, Metcheva R, Popov N, Teodorova SE, Heredia-Rojas JA, Rodríguez-de la Fuente AO, Rodríguez-Flores LE, Topashka-Ancheva M.  Biol Trace Elem Res. 2012 Jun;147(1-3):180-8.   https://www.ncbi.nlm.nih.gov/pubmed/22147334/

Novel, oxygenated clinoptilolite material efficiently removes aluminium from aluminium chloride-intoxicated rats in vivo.  Sandra Kraljević Pavelić (associate professor), Vedran Micek, Ana Filošević, Darko Gumbarević, Paula Žurga, Aleksandar Bulog, Tatjana Orct, Yasuaki Yamamoto, Tajana Preočanin, Janez Plavec, Robert Peter, Mladen Petravić, DraženVikić-Topić, KrešimirPavelić.  Microporous and Mesoporous Materials, Volume 249, 1 September 2017, Pages 146-156.  https://www.sciencedirect.com/science/article/pii/S1387181117303116?via%3Dihub

[The effect of natural zeolite on the excretion and distribution of radiocesium in rats].  [Article in Slovak] Mizik P, Hrusovský J, Tokosová M.  Vet Med (Praha). 1989 Aug;34(8):467-74. https://www.ncbi.nlm.nih.gov/pubmed/2552638

Reduction of radiocaesium absorption by sheep consuming feed contaminated with fallout from Chernobyl.  Phillippo M1, Gvozdanovic S, Gvozdanovic D, Chesters JK, Paterson E, Mills CF.  Vet Rec. 1988 Jun 4;122(23):560-3.   https://www.ncbi.nlm.nih.gov/pubmed/2842924/

Potentiated clinoptilolite: artificially enhanced aluminosilicate reduces symptoms associated with endoscopically negative gastroesophageal reflux disease and nonsteroidal anti-inflammatory drug induced gastritis.  Wilna Potgieter, Caroline Selma Samuels, and Jacques Renè Snyman.  Clin Exp Gastroenterol. 2014; 7: 215–220.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087055/

Antiviral properties of clinoptilolite, Magdalena Grce, Krešimir Pavelić.  Microporous and Mesoporous Materials, Volume 79, Issues 1–3, 1 April 2005, Pages 165-169.  https://www.sciencedirect.com/science/article/abs/pii/S1387181104004482

Effects of zeolite supplementation on parameters of intestinal barrier integrity, inflammation, redoxbiology and performance in aerobically trained subjects.  Manfred Lamprecht, corresponding author Simon Bogner, Kurt Steinbauer, Burkhard Schuetz, Joachim F. Greilberger, Bettina Leber, Bernhard Wagner, Erwin Zinser, Thomas Petek, Sandra Wallner-Liebmann, Tanja Oberwinkler, Norbert Bachl, and Gert Schippinger.  J Int Soc Sports Nutr. 2015; 12: 40.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617723/

ACTIVATED CHARCOAL

Oral activated charcoal adsorbent (AST-120) ameliorates CKD-induced intestinal epithelial barrier disruption.  Nosratola D. Vaziri, Jun Yuan, Mahyar Khazaeli, Yuichi Masuda, Hirohito Ichii, and Shuman Liu.  Am J Nephrol. 2013; 37(6): 518–525.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777856/

The effect of activated charcoal on adenine-induced chronic renal failure in rats.  Badreldin H.Ali, Mohamed Alza’abi, Aishwarya Ramkumar, Intisar Al-Lawati, Mostafa I. Waly, Sumaya Beegam, Abderrahim Nemmar, Susanne Brand, NicoleSchupp.  Food and Chemical Toxicology. Volume 65, March 2014, Pages 321-328.   https://www.sciencedirect.com/science/article/pii/S0278691513008600?via%3Dihub

Alpha-galactosidase versus active charcoal for improving sonographic visualization of abdominal organs in patients with excessive intestinal gas.   G. Maconi,∗ E. Bolzacchini, E. Radice, M. Marzocchi, and M. Badini.  J Ultrasound. 2012 Dec; 15(4): 232–238.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565684/

A nexus of progression of chronic kidney disease: charcoal, tryptophan and profibrotic cytokines.  Gerald Schulman.  Blood Purif. 2006;24(1):143-8.  https://pubmed.ncbi.nlm.nih.gov/16361855/

Zanzibar Monkeys Eat Charcoal To Counteract Toxins." ScienceDaily. Univeristy of Wyoming. ScienceDaily, 1 September 1997.  https://www.sciencedaily.com/releases/1997/09/970901072246.htm
 

CHLORELLA

Evaluation of Chlorella as a Decorporation Agent to Enhance the Elimination of Radioactive Strontium from Body.  Kazuma Ogawa, Tadahisa Fukuda, Jaegab Han, Yoji Kitamura, Kazuhiro Shiba, and Akira Odani.  PLoS One. 2016; 11(2): e0148080.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734693/

The Influence of Chlorella and Its Hot Water Extract Supplementation on Quality of Life in Patients with Breast Cancer.  Naoto Noguchi,  Isao Maruyama, and Akira Yamada.  Evid Based Complement Alternat Med. 2014; 2014: 704619.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988967/

Chlorella diet alters mitochondrial cardiolipin contents differentially in organs of Danio rerio analyzed by a lipidomics approach.   Qun Chen, Editor.  PLoS One. 2018; 13(3): e0193042. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832209/

Chlorella sorokiniana induces mitochondrial-mediated apoptosis in human non-small cell lung cancer cells and inhibits xenograft tumor growth in vivo. Ping-Yi Lin, Ching-Tsan Tsai, Wan-Ling Chuang, Ya-Hsuan Chao, I-Horng Pan, Yu-Kuo Chen, Chi-Chen Lin, corresponding author and Bing-Yen Wang, corresponding author.  BMC Complement Altern Med. 2017; 17: 88.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286777/ 

Evaluation of antiangiogenic and antiproliferative potential of the organic extract of green algae chlorella pyrenoidosa. Mahender Kyadari, Tasneem Fatma, Rajvardhan Azad, and Thirumurthy Velpandian.  Indian J Pharmacol. 2013 Nov-Dec; 45(6): 569–574.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847245/

Chlorella vulgaris triggers apoptosis in hepatocarcinogenesis-induced rats* Emey Suhana Mohd Azamai, Suhaniza Sulaiman, Shafina Hanim Mohd Habib, Mee Lee Looi, Srijit Das, Nor Aini Abdul Hamid, Wan Zurinah Wan Ngah, and Yasmin Anum Mohd Yusof. J Zhejiang Univ Sci B. 2009 Jan; 10(1): 14–21.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613958/

Nutrigenomic Studies of Effects of Chlorella on Subjects with High-Risk Factors for Lifestyle-Related Disease. Toru Mizoguchi, Isao Takehara, Tohru Masuzawa, Toshiro Saito, and Yo Naoki. Journal of Medicinal Food Vol. 11, No. 3.  https://www.liebertpub.com/doi/abs/10.1089/jmf.2006.0180

ALGINIC ACID

Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects.  Sergey N. Fedorov, Svetlana P. Ermakova, Tatyana N. Zvyagintseva, and Valentin A. Stonik*.  Mar Drugs. 2013 Dec; 11(12): 4876–4901.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877892/

Anti-Cancer Therapeutic Alginate-Based Tissue Sealants for Lung Repair. Spencer L. Fenn, Patrick N. Charron, and Rachael A. Oldinski.  ACS Appl Mater Interfaces. 2017 Jul 19; 9(28): 23409–23419. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546308/

Biological importance of marine algae.  Ali A. El Gamal.  Saudi Pharm J. 2010 Jan; 18(1): 1–25.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731014/

Targeting of crosstalk between tumor and tumor microenvironment by β‐D mannuronic acid (M2000) in murine breast cancer model.  Fatemeh Hosseini,  Hadi Hassannia,  Ahmad Mahdian‐Shakib,  Farhad Jadidi‐Niaragh, Seyed Ehsan Enderami, Mohammadjavad Fattahi, Ali Anissian,  Abbas Mirshafiey, corresponding author  and Parviz Kokhaei corresponding author.  Cancer Med. 2017 Mar; 6(3): 640–650.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345625/

Esophageal cancer research today and tomorrow: Lessons from algae and other perspectives. Vladlena Tiasto, Valeriia Mikhailova, Valeriia Gulaia, Valeriia Vikhareva, Boris Zorin, Alexandra Kalitnik, and Alexander Kagansky.  AIMS Genet. 2018; 5(1): 75–90.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690251/

 

CITRUS PECTIN

Heat-Modified Citrus Pectin Induces Apoptosis-Like Cell Death and Autophagy in HepG2 and A549 Cancer Cells.  Lionel Leclere,  Maude Fransolet, Francois Cote, Pierre Cambier,  Thierry Arnould, Pierre Van Cutsem, and Carine Michiels.  PLoS One. 2015; 10(3): e0115831.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368604/

Chemoprevention of Low-Molecular-Weight Citrus Pectin (LCP) in Gastrointestinal Cancer Cells.  Shi Wang, Pei Li, Sheng-Min Lu, and Zhi-Qiang Ling.  Int J Biol Sci. 2016; 12(6): 746–756.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870717/

Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3. Tian Fang, Dan-dan Liu, He-ming Ning, Dan Liu, Jing-ya Sun, Xiao-jing Huang, Yu Dong, Mei-yu Geng, Shi-feng Yun, corresponding author Jun Yan, corresponding author and Rui-min Huang corresponding author.  Acta Pharmacol Sin. 2018 Dec; 39(12): 1885–1893.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289393/

Inhibitory effect of modified citrus pectin on liver metastases in a mouse colon cancer model.  Hai-Ying Liu, Zhi-Liang Huang, Guo-Hua Yang, Wei-Qun Lu, and Nan-Rong Yu.  World J Gastroenterol. 2008 Dec 28; 14(48): 7386–7391.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778124/

The benefits of modified citrus pectin  https://www.verywellhealth.com/the-benefits-of-modified-citrus-pectin-89481

Integrative Medicine and the Role of Modified Citrus Pectin/Alginates in Heavy Metal Chelation and Detoxification – Five Case Reports.  Isaac Eliaz, Elaine Weil, Barry Wilk.  Forschende Komplementärmedizin / Research in Complementary Medicine 14(6):358-64 · January 2008 https://www.researchgate.net/publication/5632959_Integrative_Medicine_and_the_Role_of_Modified_Citrus_PectinAlginates_in_Heavy_MetIntegrative_Medicine_and_the_Role_of_Modified_Citrus_PectinAlginates_in_Heavy_Metal_Chelation_and_Detoxification_-_Five

FULVIC & HUMIC ACID

Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes.  John Winkler and Sanjoy Ghosh corresponding author.  J Diabetes Res. 2018; 2018: 5391014.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151376/

Lead binding to soil fulvic and humic acids: NICA-Donnan modeling and XAFS spectroscopy.  Xiong J1, Koopal LK, Tan W, Fang L, Wang M, Zhao W, Liu F, Zhang J, Weng L.  Environ Sci Technol. 2013 Oct 15;47(20):11634-42. doi: 10.1021/es402123v. Epub 2013 Oct 1.   https://www.ncbi.nlm.nih.gov/pubmed/24040886

Fulvic and Humic Acid Benefits  https://wellnessmama.com/61297/fulvic-humic-acid-benefits/

Humic Acid Enhances Wound Healing in the Rat Palate.  Metin Çalışır, Aysun Akpınar, Ahmet Cemil Talmaç, Aysan Lektemur Alpan, and Ömer Fahrettin Göze.  Evid Based Complement Alternat Med. 2018; 2018: 1783513.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092992/ 

Humic Substances: Nature's Most Versatile Materials, 1st Edition.  Elham A. Ghabbour, Geoffrey Davies by Taylor & Francis Published October 30, 2003

Humic acid inhibits HBV-induced autophagosome formation and induces apoptosis in HBV-transfected Hep G2 cells.  Kishor Pant,a, Ajay K. Yadav, Parul Gupta, Abhishek Singh Rathore, Baibaswata Nayak, and Senthil K. Venugopalb.  Sci Rep. 2016; 6: 34496.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052648/

Fulvic acid promotes extracellular anti-cancer mediators from RAW 264.7 cells, causing to cancer cell death in vitro.  Rajapaksha Gedara Prasad Tharanga Jayasooriya, Matharage Gayani Dilshara,  Chang-HeeKanga, Seungheon Lee, Yung Hyun Choi, Yong Kee Jeong, Gi-Young Kim.  International Immunopharmacology  Volume 36, July 2016, Pages 241-248.   https://www.sciencedirect.com/science/article/pii/S1567576916301734

Glucan and Humic Acid: Synergistic Effects on the Immune System.  Vaclav Vetvicka, Roberto Baigorri, Angel M. Zamarreño, Jose M. Garcia-Mina, and Jean-Claude Yvin.  Journal of Medicinal FoodVol. 13, No. 4.  https://www.liebertpub.com/doi/abs/10.1089/jmf.2009.0178

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